Master’s Thesis at the University of Babylon on Adolescent Patients with Asthma
As part of the activities of the Department of Clinical Biochemistry, a master’s thesis defense was held at the College of Medicine, University of Babylon, by the student Maryam Hamed Abdul Sattar, entitled: “Predictive Significance of Irisin and Myeloperoxidase in Adolescent Patients with Asthma”, supervised by Prof. Dr. Alaa Jafar Mehrath and Prof. Dr. Suhair Issa Hussein.
The defense session was attended by the Head of the Department, Prof. Dr. Tareq Hussein Mughair, along with several faculty members, researchers, academics, and postgraduate students.
During her defense, the researcher explained that bronchial asthma is a chronic inflammatory disease characterized by airway obstruction or narrowing, hyperresponsiveness, and recurrent bronchospasm episodes. The pathophysiology of asthma involves complex interactions between immune responses and metabolic pathways. Key biomarkers, such as irisin, myeloperoxidase, and glucose, have been linked to inflammation regulation and metabolic dysfunction in asthma. Monitoring these biomarkers may provide valuable insights for disease management and prognosis.
Irisin, also known as myokine released during physical exercise, is secreted by human muscles and is associated with the health benefits of physical activity, such as anti-inflammatory effects and glucose balance regulation. Given the significant benefits of exercise-induced irisin, this study proposes the potential use of irisin as a therapeutic agent for patients with bronchial asthma.
Myeloperoxidase (MPO) is an oxidative enzyme that generates free radicals and contributes to oxidative stress, which is involved in the pathogenesis of bronchial asthma, making it a potential biomarker for airway inflammation and disease activity.
The study aimed to evaluate serum levels of irisin, myeloperoxidase, and glucose in adolescents with bronchial asthma compared to healthy individuals. Additionally, the study investigated the interrelationships between these biomarkers and their potential role in asthma progression. The predictive significance of these biomarkers for disease outcomes was also assessed.
The study results indicate that irisin plays a dual role in regulating glucose metabolism and inflammation, making it a promising target for therapeutic intervention, as it counteracts the negative effects of myeloperoxidase, which shows harmful effects in patients with bronchial asthma. The study recommends moderate physical exercise, known to naturally increase irisin levels, for patients with bronchial asthma to enhance metabolic health and reduce inflammatory responses.
These findings also highlight the importance of monitoring levels of irisin, myeloperoxidase, immunoglobulin E (IgE), and glucose in asthma patients to gain a better understanding and predict long-term disease outcomes