Media University of Babylon | Master’s Thesis at the University of Babylon on Autism Spectrum Disorder

Media University of Babylon - Faculty of Medicine

Master’s Thesis at the University of Babylon on Autism Spectrum Disorder

By : Zaynab Kadhim Ameen Awadh

Date : 15/9/2025 08:01:10 AM

Master’s Thesis at the University of Babylon on Autism Spectrum Disorder
The Department of Pharmacology and Toxicology at the College of Medicine, University of Babylon, held the defense of a master’s thesis by student Al-Hassan Waleed Jawad, titled “Evaluation of the Protective Effects of Acetyl-11-Keto-?-Boswellic Acid (AKBA) in a Prenatal Valproic Acid-Induced Autism Model in Mice”, under the supervision of Prof. Dr. Salman Mohammed Salman and Prof. Dr. Hameed Ridha Sadiq.
During his defense, the researcher explained that Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication.
The study aimed to evaluate the therapeutic effects of AKBA on autism-like behaviors and biochemical markers in a mouse model in which autism was induced by prenatal exposure to sodium valproate.
The results showed that AKBA, at both studied doses, increased the time the mice spent interacting with an unfamiliar mouse in the social interaction test. It also demonstrated an anxiolytic effect, reducing ASD-related symptoms such as anxiety, fear, and hyperactivity in the open-field test.
The study further revealed that AKBA exhibited strong antioxidant activity compared to risperidone, particularly at the 5 mg/kg dose, as evidenced by a significant reduction in lipid peroxidation. However, the anti-inflammatory effect of AKBA was less potent than risperidone, even though AKBA still showed good anti-inflammatory activity in the non-ASD control groups.
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