Media University of Babylon | Master’s Thesis on Asthma Patients at the College of Medicine, University of Babylon

Media University of Babylon - Faculty of Medicine

Master’s Thesis on Asthma Patients at the College of Medicine, University of Babylon

By : Zaynab Kadhim Ameen Awadh

Date : 28/4/2025 22:43:12 PM

Master’s Thesis on Asthma Patients at the College of Medicine, University of Babylon
As part of the activities of the Department of Clinical Biochemistry, a master’s thesis defense was held at the College of Medicine, University of Babylon, for student Suhair Abdulwahab Kazem, titled:
“Evaluation of Serum Chitinase-3-like Protein 1, 14-3-3 Beta Protein, and Some Electrolyte Levels in Asthma Patients,”
under the supervision of Assistant Professor Dr. Zina Ali Abbas and Professor Dr. Tareq Hussein Mughir.
During her defense, the researcher explained that asthma is a serious global health problem affecting all age groups, with its prevalence increasing in many developing countries, resulting in rising treatment costs and a growing burden on patients and society.
Currently, the diagnosis and management of asthma largely depend on symptoms and pulmonary function test results. Asthma attacks typically last from several minutes to several hours. Persistent asthma results in continuous airway obstruction that can last for days or weeks.
The results of the present study demonstrated a significant increase in Chitinase-3-like Protein 1 levels among asthma patients compared to the healthy control group (P < 0.05), with a mean of (313.72 ± 72.56), ranging from 198.7 to 440.05, while the healthy control group had a mean of 177.05 ± 65.78, ranging from 55.01 to 286.35.
There was also a significant increase in 14-3-3 Beta Protein levels in the asthma patient group compared to the healthy controls (P < 0.05), with a mean of (556.59 ± 88.45), ranging between 404.85 and 760.4, while the healthy controls had a mean of 422.69 ± 68.86, ranging between 252.32 and 520.7.
Additionally, a significant elevation was observed in Immunoglobulin E (IgE) and IL-6 levels among asthma patients compared to healthy controls (P < 0.05).
The study also found a significant difference in magnesium levels, while calcium and potassium levels showed no significant difference between the patient and control groups.
It is likely that Chitinase-3-like Protein 1 and 14-3-3 Beta Protein play an important role in the inflammation associated with asthma, and they may potentially serve as predictive markers for asthma control and the risk of poor disease management