Media University of Babylon | Babylon College of Medicine Discusses Two Researches for the Iraqi Board Fellowship in Pathology (Histopathology)

Media University of Babylon - Faculty of Medicine

Babylon College of Medicine Discusses Two Researches for the Iraqi Board Fellowship in Pathology (Histopathology)

By : Zaynab Kadhim Ameen Awadh

Date : 30/12/2025 50:13:12 PM

Babylon College of Medicine Discusses Two Researches for the Iraqi Board Fellowship in Pathology (Histopathology)
The College of Medicine at the University of Babylon hosted the defense of two Board researches submitted by candidates from the Iraqi Council for Medical Specializations in the Department of Pathology/Histopathology. These discussions are primary requirements for the attainment of the Fellowship of the Iraqi Board.
First research: TROP-2 Expression in Thyroid Diseases
Researcher: Doaa Zuhair Jaber
Supervisor: Professor Dr. Sura Salman Abdul-Moneim
Title: "Evaluation of Immunohistochemical Expression of Trophoblast Antigen-2 (TROP-2) in a Range of Thyroid Diseases and Determination of its Diagnostic Value"
Research Summary:
The study aimed to evaluate the immunohistochemical (IHC) expression of TROP-2 across various thyroid pathologies to determine its diagnostic utility. Analyzing 64 cases, the study found that TROP-2 expression was significantly and preferentially localized in Papillary Thyroid Carcinoma (PTC), while it was absent or weak in most benign conditions and non-papillary malignancies. High TROP-2 scores showed a statistically significant correlation with clinicopathological features, including gender, histological subtype, and tumor size. These findings support the role of TROP-2 as an effective ancillary IHC marker for differentiating PTC from other thyroid lesions, enhancing its importance in routine pathological assessment.
Second Research: TRPS1 Expression in Breast Cancer
Researcher: Sura Jaber Hamza
Supervisor: Professor Dr. Ali Zaki Naji Al-Asadi
Title: "Evaluation of Immunohistochemical Expression of TRPS1 Protein in Breast Cancer and Studying its Correlation with Various Molecular Subtypes"
Research Summary:
The study investigated TRPS1 (Trichorhinophalangeal Syndrome 1), a nuclear transcription factor belonging to the GATA family, which plays a vital role in regulating the growth and differentiation of mammary epithelial cells. TRPS1 is considered a highly sensitive and specific biomarker for breast cancer, showing robust expression in primary breast malignancies. IHC staining was performed on tissue sections to detect TRPS1 protein reactivity and analyze its association with molecular subtypes.
Key Results:
• 78% of the cases demonstrated positive TRPS1 expression, while 22% were negative.
• High levels of TRPS1 expression were recorded in 64% of the cases.
• A statistically significant correlation was found between TRPS1 expression and molecular subtypes, with the highest positivity rates observed in Luminal A and Luminal B subtypes.